email forum - by joining the group e-mail forum you will be in contact with Alpha patients, their families, carers and friends living throughout the UK and overseas. We are a friendly group, and between us we have a wealth of knowledge and experience to share. There is always someone to help with any worries or queries you might have.

What is Alpha-1 Antitrypsin Deficiency?

Alpha-1 Antitrypsin Deficiency also known as Alpha-1, A1AD or AATD is an inherited, genetic condition that is passed on from generation to generation. As the name suggests it is a deficiency of alpha-1 antitrypsin (AAT) in the bloodstream. AAT is an enzyme produced in the liver to help protect the tissues of the body during infections. The low level of AAT in the blood occurs because the AAT is abnormal and cannot be released from the liver at the normal rate. This leads to a build up of abnormal AAT in the liver that can cause liver disease and a decrease of AAT in the blood that can lead to lung disease.


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Latest News

Specialised Alpha-1 Service Endorsed by CRG
21 Jul 2014 18:44

Alpha-1 Alliance’s application for highly specialised Alpha-1 service endorsed by Clinical Reference Group
The Alpha-1 Alliance is delighted to announce that the Clinical Reference Group (CRG) for  [ ... ]

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Alpha-1 Alliance Secures Clinical Expert Support
21 Jul 2014 18:32

Alpha-1 Alliance secures wide clinical expert support for a national service at Advisory Board

Yesterday, the Alpha-1 Alliance brought together clinical experts specialising in Alpha-1 and Alpha-1 pati [ ... ]

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Minister answers Parliamentary Question on A1AD
12 Jun 2014 19:27

Minister answers Parliamentary Question on Alpha-1 Antitrypsin Deficiency - In May, the Alpha-1 Alliance met with Peter Aldous, Conservative MP for Waveney, to discuss the unmet medical need of patien [ ... ]

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Dr Ravi Mahadeva steps down as Chair of Alliance
04 Jun 2014 19:14

Dr Ravi Mahadeva has resigned as Chair of the Alpha-1 Alliance due to a conflict of interest in relation to his work with NHS England’s Specialised Respiratory Disease Clinical Reference Group (CRG) [ ... ]

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Alpha-1 Community meets Jeremy Hunt MP
04 Jun 2014 19:06

The Secretary of State for Health, Jeremy Hunt MP, met with representatives of the Alpha-1 community last Tuesday (13th May 2014) at the Department of Health to discuss the unmet medical need of Alph [ ... ]

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Letters from Cabinet Secretary Health on Alpha-1
21 May 2014 19:30

As part of the campaign in the Scottish Parliament, Members of the Scottish Parliament (MSPs) Malcolm Chisholm and Graeme Dey wrote to the Cabinet Secretary for Health and Wellbeing, Alex Neil MSP, on [ ... ]

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