email forum - by joining the group e-mail forum you will be in contact with Alpha patients, their families, carers and friends living throughout the UK and overseas. We are a friendly group, and between us we have a wealth of knowledge and experience to share. There is always someone to help with any worries or queries you might have.

What is Alpha-1 Antitrypsin Deficiency?

Alpha-1 Antitrypsin Deficiency also known as Alpha-1, A1AD or AATD is an inherited, genetic condition that is passed on from generation to generation. As the name suggests it is a deficiency of alpha-1 antitrypsin (AAT) in the bloodstream. AAT is an enzyme produced in the liver to help protect the tissues of the body during infections. The low level of AAT in the blood occurs because the AAT is abnormal and cannot be released from the liver at the normal rate. This leads to a build up of abnormal AAT in the liver that can cause liver disease and a decrease of AAT in the blood that can lead to lung disease.

Newsletter Autumn 2019 Now Available

Autumn 2019 Alpha-1 UK Newsletter Issue 18
Now Available

Contains 28 pages full of News and Information including:

Charity Annual Update, Members Stories and much more


Top Story


The following is a statement from Professor David Parr, University Hospitals Coventry & Warwickshire

Information on the impact of novel coronavirus (COVID-19) on patients with alpha-1 antitrypsin deficiency is not yet available. It is unlikely that AATD confers an increased risk of becoming infected with the virus. However, the impact of infection with COVID-19 in AATD is likely to be greater than in the general population. Patients with emphysema are less likely to cope with the development of a viral pneumonia and it is likely that the lasting effects of a viral pneumonia will be greater in patients with AATD than in the general population (ie AATD patients are likely to be at high-risk).

The landscape is rapidly evolving and alphas are advised to monitor events on a daily basis, since the likelihood of infection increases with the increasing number of cases in the UK. Advice is available to employers from Public Health England, the NHS and the UK government. Information for the public is widely available on the internet and the following link should provide a reliable source of current information:


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