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What is Alpha-1 Antitrypsin Deficiency?

Alpha-1 Antitrypsin Deficiency also known as Alpha-1, A1AD or AATD is an inherited, genetic condition that is passed on from generation to generation. As the name suggests it is a deficiency of alpha-1 antitrypsin (AAT) in the bloodstream. AAT is an enzyme produced in the liver to help protect the tissues of the body during infections. The low level of AAT in the blood occurs because the AAT is abnormal and cannot be released from the liver at the normal rate. This leads to a build up of abnormal AAT in the liver that can cause liver disease and a decrease of AAT in the blood that can lead to lung disease.

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Latest News

ERS to Honor Alpha-1 Researcher Robert Stockley
28 Aug 2014 20:50

European Respiratory Society to honor longtime UK Alpha-1 researcher Robert Stockley The European Respiratory Society will honor Robert Stockley, MD, with its Presidential Award at the 14 ERS Int [ ... ]

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Alpha-1 Global Launches Website
27 Aug 2014 18:33

Alpha-1 Global launches website, linking Alphas worldwide
Today marks an exciting milestone for the Alpha-1 community worldwide: The Alpha-1 Global website alpha-1global.org is up and running.
The s [ ... ]

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Update Review Specialised Service Commissioning
15 Aug 2014 19:17

Minister gives update on review of Specialised Service Commissioning In April, NHS England established a specialised task force to make some immediate improvements to the commissioning of specialised [ ... ]

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Specialised Alpha-1 Service Endorsed by CRG
21 Jul 2014 18:44

Alpha-1 Alliance’s application for highly specialised Alpha-1 service endorsed by Clinical Reference Group
The Alpha-1 Alliance is delighted to announce that the Clinical Reference Group (CRG) for  [ ... ]

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Alpha-1 Alliance Secures Clinical Expert Support
21 Jul 2014 18:32

Alpha-1 Alliance secures wide clinical expert support for a national service at Advisory Board

Yesterday, the Alpha-1 Alliance brought together clinical experts specialising in Alpha-1 and Alpha-1 pati [ ... ]

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Minister answers Parliamentary Question on A1AD
12 Jun 2014 19:27

Minister answers Parliamentary Question on Alpha-1 Antitrypsin Deficiency - In May, the Alpha-1 Alliance met with Peter Aldous, Conservative MP for Waveney, to discuss the unmet medical need of patien [ ... ]

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